Oser Lab - New Targeted Approaches for Small Cell Lung Cancer
Welcome to Oser Lab!
Laboratory Overview: The Oser laboratory uses CRISPR/Cas9 functional genomics and CRISPR/Cas9 in vivo editing to uncover vulnerabilities in small cell lung cancer (SCLC) related to tumor suppressor genes, undruggable oncogenic transcription factors, and neuroendocrine differentiation. We also use CRISPR/Cas9-based in vivo genetically-engineered mouse models of SCLC to understand how epigenetic modifying enzymes modulate neuroendocrine plasticity and SCLC subtypes and how this influences tumor immunogenicity.
Mission: We seek to elucidate new mechanisms that are required for SCLC tumorigenesis. Our ultimate goal is to make discoveries that will lay the preclinical foundation for the development of new therapeutic approaches for SCLC. We are deeply committed to mentoring highly motivated scientists and physician-scientists.
We are currently seeking highly motivated individuals at all levels (post-doctoral fellows, graduate students, and research technicians) that are excited to pursue functional genomics and in vivo mouse modeling approaches aimed at identifying new therapeutic strategies for small cell lung cancer. Please contact Dr. Oser via email (email@example.com) to apply.