Dr. Matthew G. Oser, M.D., Ph.D.Principal Investigator Dr. Oser is a physician-scientist and an attending medical oncologist in the Lowe Center for Thoracic Oncology at the Dana-Farber Cancer Institute. He received his B.A. in Biology from Oberlin College. He subsequently received his M.D. and Ph.D. from Albert Einstein College of Medicine, where he did his graduate work in the lab of Dr. John Condeelis studying mechanisms of tumor cell invasion in breast cancer. He then completed residency training in Internal Medicine at the Brigham and Women's Hospital and a fellowship in Medical Oncology at the Dana-Farber/Harvard Cancer Center Program where he became interested in thoracic oncology. He completed his postdoctoral fellowship in Dr. William G. Kaelin Jr.'s laboratory at the Dana-Farber Cancer Institute where he used CRISPR/Cas9 screening to identify new targeted therapy approaches for small cell lung cancer and also used CRISPR/Cas9 to develop a new genetically engineered mouse model of small cell lung cancer. He is originally from Columbus, Ohio.
Dr. Leslie Duplaquet, Ph.D. Postdoctoral Fellow Dr. Duplaquet is a postdoctoral fellow focused on understanding mechanisms that function to regulate neuroendocrine transcription factors in small cell lung cancer. She is originally from France and completed her B.A. in 2013 at the University of Lille, France and her Ph.D. thesis in 2018 with Dr. David Tulasne at the University of Lille, France.
Dr. Deli Hong, Ph.D. Postdoctoral Fellow Dr. Hong is a postdoctoral fellow focused on understanding mechanisms that function to control neuroendocrine differentiation in small cell lung cancer. He is originally from China and completed his B.S. at the University of Nanjing in China. He completed an M.S. at Worcester Polytechnic Institute in Worcester, MA, and his Ph.D. in the laboratory of Dr. Gary Stein at the University of Massachusetts Medical School in 2018.
Amin H. Sabet, B.A. Research Assistant Mr. Sabet is a research assistant in the laboratory and slowly becoming an expert in CRISPR/Cas9 screening. He is originally from Egypt and completed his B.A. at Macalester College in 2018 where he majored in Chemistry and Biology.
Yavuz Durmaz, B.S. Research Assistant Mr. Durmaz joined our laboratory as a research assistant in 2020. He is originally from Virginia and completed his B.S. at Washington and Lee University in 2020 where he majored in Biochemistry. His research is focused on understanding how repression of tumor suppressor programs are required for neuroendocrine differentiation and survival in small cell lung cancer.
Dr. Hsiao-Yun Chen, Ph.D. Postdoctoral Fellow Dr. Chen is a postdoctoral fellow focused on understanding key determinants that predict sensitivity to epigenetic inhibitors in small cell lung cancer. She is originally from Taiwan and completed her PhD in Dr. Chiou Shin-Hwa’s laboratory at National Yang-Ming University studying RNA binding proteins in cancer. She joined the Oser laboratory in October 2020.
Dr. Yixiang Li, Ph.D. Postdoctoral Fellow Dr. Li is a postdoctoral fellow focused on understanding oncogenic pathways that oppose the neuroendocrine phenotype in small cell lung cancer and therefore can function as bypass mechanisms to overcome targeted approaches that disrupt neuroendocrine differentiation. He is originally from China and attended Emory University for his PhD where he did his thesis work in Dr. Jin-Tang Dong's laboratory working on drug resistance in prostate cancer. He joined the Oser laboratory in October 2020.