Matthew G. Oser, M.D., Ph.D.Principal Investigator Dr. Oser is a Physician-Scientist in the Department of Medical Oncology at the Dana-Farber Cancer Institute and an Assistant Professor of Medicine at Harvard Medical School. He is also an Associate Member at the Broad Institute and an Attending Medical Oncologist in the Lowe Center for Thoracic Oncology at the Dana-Farber Cancer Institute. He received his B.A. in Biology from Oberlin College. He subsequently received his M.D. and Ph.D. from Albert Einstein College of Medicine, where he did his graduate work in the lab of Dr. John Condeelis studying mechanisms of tumor cell invasion in breast cancer. He then completed residency training in Internal Medicine at the Brigham and Women's Hospital and a fellowship in Medical Oncology at the Dana-Farber/Harvard Cancer Center Program where he became interested in thoracic oncology. He completed his postdoctoral fellowship in Dr. William G. Kaelin Jr.'s laboratory at the Dana-Farber Cancer Institute where he used CRISPR/Cas9 screening to identify new targeted therapy approaches for small cell lung cancer (SCLC) and also used CRISPR/Cas9 to develop a new genetically engineered mouse model of small cell lung cancer. In 2019, he began leading a research laboratory at DFCI focused on understanding SCLC pathogenesis with the goal to bring better therapies to our patients with SCLC. He is originally from Columbus, Ohio.
Deli Hong, Ph.D.Postdoctoral Fellow Dr. Hong is a postdoctoral fellow who joined the Oser laboratory in May of 2019. His post-doctoral work is focused on understanding mechanisms that promote tumor immunogenicity in SCLC. He is originally from China and completed his B.S. at the University of Nanjing in China. He completed an M.S. at Worcester Polytechnic Institute in Worcester, MA, and his Ph.D. in the laboratory of Dr. Gary Stein at the University of Massachusetts Medical School in 2018.
Leslie Duplaquet, Ph.D. Postdoctoral Fellow Dr. Duplaquet is a postdoctoral fellow who joined the Oser laboratory in August of 2019. Her post-doctoral work is focused on understanding mechanisms that function to regulate neuroendocrine transcription factors in small cell lung cancer. She is originally from France and completed her B.A. in 2013 at the University of Lille, France and her Ph.D. thesis in 2018 with Dr. David Tulasne at the University of Lille, France.
Yixiang Li, Ph.D. Postdoctoral Fellow Dr. Li is a postdoctoral fellow focused on understanding how modulation of epigenetic modifiers in SCLC impacts its neuroendocrine phenotype and the consequences of this on tumor immunogenicity. His work utilizes single cell approaches using in vivo immunocompetent mouse models. He is originally from China and attended Emory University for his PhD where he did his thesis work in Dr. Jin-Tang Dong's laboratory working on drug resistance in prostate cancer. He joined the Oser laboratory in October 2020.
Shilpa Singh, Ph.D. Postdoctoral Fellow Dr. Singh is a postdoctoral fellow focused on understanding cell cycle regulation and mechanisms of protein homeostasis of SCLC. She joined the Oser laboratory in November of 2021. She trained in Dr. Swati Deb's laboratory for her PhD at Virginia Commonwealth University where she focused on mutant p53 and replication stress.
Keita Masuzawa, M.D., Ph.D. Postdoctoral Fellow Dr. Masuzawa is a postdoctoral fellow who started in the Oser laboratory in April of 2022. His post-doctoral work is focused on using CRISPR/Cas9 screening approaches to understand the transcriptional regulation of oncoproteins in SCLC. He is from Japan where he trained at Keio University as a pulmonologist and received his PhD also at Keio University in 2019.
Tianchu Wang, Ph.D. Postdoctoral Fellow Dr. Wang is a postdoctoral fellow who started in the Oser laboratory in September of 2023. His post-doctoral work is focused on epigenetic regulation of ASCL1-driven neuroendocrine differentiation in small cell lung cancer and interested in exploring new immunotherapy for SCLC. He received PhD at Mayo Clinic where he focused on epigenetic regulation of kidney cancer progression using celular assays and bioinformatic analysis of omics data.
Xinyue Li, B.S. Research Technician Xinyue is a research technician who started in the Oser laboratory in summer of 2023. Her work is focused on understanding the mechanism of targeting the SCLC transcription factor by using both experimental and computational methods. Additionally she is working on establishing human SCLC CRISPRi cell lines. She received B.S. degree at Case Western Reserve University, Ohio. She is originally from China.
Hyeonseo Cho, B.A. Research Technician Hyeonseo is a research technician who started in the Oser laboratory in summer of 2023. Her work is focused on epigenetic regulation on SCLC phenotype and SCLC transformation, helping Dr. Li's project. She received B.A. degree at Boston University. She is origianlly from South Korea.
Amin H. Sabet, B.A. Research Assistant 2018-2020 Mr. Sabet was a research assistant in the laboratory from 2018-2020 and was the first member of the Oser laboratory. He is originally from Egypt and completed his B.A. at Macalester College in 2018 where he majored in Chemistry and Biology. In 2021, he began graduate school at Memorial Sloan Kettering and recently joined Dr. Charlie Rudin's laboratory.
Hsiao-Yun Chen, Ph.D. Postdoctoral Fellow 2020-2021 Dr. Chen was a postdoctoral fellow in the laboratory from 2020-2021 where she studied how RNA-binding proteins modulate the neuroendocrine phenotype of SCLC. She is now a senior scientist at New Equilibrium Biosciences in Cambridge, MA.
Yavuz Durmaz, B.S. Research Assistant 2020-2022 Mr. Durmaz was a research technician in the laboratory from 2020-2022. He left the lab for medical school going home to Virginia where he started medical school at Virginia Tech in 2022.